2VWW
ephB4 kinase domain inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EPHRIN TYPE-B RECEPTOR 4 | polymer | 302 | 33934.8 | 1 | UniProt (P54760) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | TYROSINE-PROTEIN KINASE RECEPTOR HTK, TYROSINE-PROTEIN KINASE TYRO11 |
| 2 | B (A) | N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE | non-polymer | 430.8 | 1 | Chemie (7X2) | |||
| 3 | C (A) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 598 - 899 (UniProt: P54760)
| PDB | External Database | Details |
|---|---|---|
| Glu 774 | Tyr 774 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33934.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 430.8 | |
| All* | Total formula weight | 34365.7 |
