2VWN
Aminopyrrolidine Factor Xa inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ACTIVATED FACTOR XA HEAVY CHAIN | polymer | 241 | 27173.0 | 1 | UniProt (P00742) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | |
| 2 | B (L) | FACTOR X LIGHT CHAIN | polymer | 55 | 6060.8 | 1 | UniProt (P00742) Pfam (PF14670) | HOMO SAPIENS (HUMAN) | |
| 3 | C (A) | 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide | non-polymer | 490.9 | 1 | Chemie (H25) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, H (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | I, J (A, L) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A: 16 - 251 (UniProt: P00742)
| PDB | External Database | Details |
|---|---|---|
| Glu 150 | Arg 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33233.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 647.9 | |
| All* | Total formula weight | 33881.7 |
