2VWM
Aminopyrrolidine Factor Xa inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ACTIVATED FACTOR XA HEAVY CHAIN | polymer | 241 | 27173.0 | 2 | UniProt (P00742) Pfam (PF00089) In PDB | HOMO SAPIENS (HUMAN) | |
2 | K, L | FACTOR X LIGHT CHAIN | polymer | 55 | 6060.8 | 2 | UniProt (P00742) Pfam (PF14670) In PDB | HOMO SAPIENS (HUMAN) | |
3 | A, B | (4R)-4-{[(5-chlorothiophen-2-yl)carbonyl]amino}-N-(cyclopropylmethyl)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-L-prolinamide | non-polymer | 572.1 | 2 | Chemie (LZI) | |||
4 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | water | water | 18.0 | 561 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 251 (UniProt: P00742)
PDB | External Database | Details |
---|---|---|
Glu 150 | Arg 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 66467.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1190.1 | |
All* | Total formula weight | 67657.7 |