2VVV
Aminopyrrolidine-related triazole Factor Xa inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ACTIVATED FACTOR XA HEAVY CHAIN | polymer | 241 | 27173.0 | 1 | UniProt (P00742) Pfam (PF00089) In PDB | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR X |
| 2 | L | FACTOR X LIGHT CHAIN | polymer | 55 | 6060.8 | 1 | UniProt (P00742) Pfam (PF14670) In PDB | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR X |
| 3 | A | 5-chloro-N-[1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-1H-1,2,4-triazol-3-yl]thiophene-2-carboxamide | non-polymer | 472.9 | 1 | Chemie (H21) | |||
| 4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A: 16 - 251 (UniProt: P00742)
| PDB | External Database | Details |
|---|---|---|
| Glu 150 | Arg 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33233.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 535.9 | |
| All* | Total formula weight | 33769.7 |
