2VVC
Aminopyrrolidine Factor Xa inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ACTIVATED FACTOR XA HEAVY CHAIN | polymer | 241 | 27173.0 | 2 | UniProt (P00742) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | |
| 2 | C, D (K, L) | FACTOR X LIGHT CHAIN | polymer | 55 | 6060.8 | 2 | UniProt (P00742) Pfam (PF14670) | HOMO SAPIENS (HUMAN) | |
| 3 | E, H (A, B) | 5-chloro-N-[(3S,4S)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)-4-methoxypyrrolidin-3-yl]thiophene-2-carboxamide | non-polymer | 505.0 | 2 | Chemie (LZF) | |||
| 4 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | G, I (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | J, K, L, M (A, B, K, L) | water | water | 18.0 | 574 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 251 (UniProt: P00742)
| PDB | External Database | Details |
|---|---|---|
| Glu 150 | Arg 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 66467.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1096.0 | |
| All* | Total formula weight | 67563.6 |
