2VTX

ACTIVATION OF NUCLEOPLASMIN, AN OLIGOMERIC HISTONE CHAPERONE, CHALLENGES ITS STABILITY

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	NPM-A PROTEIN	polymer	120	13384.2	9	UniProt (Q6GQG6) Pfam (PF03066) UniProt (by SIFTS) (P05221)	XENOPUS LAEVIS (AFRICAN CLAWED FROG)	CORE NUCLEOPLASMIN WITH 8 MUTATIONS
2	I (J)	NPM-A PROTEIN	polymer	120	13396.2	1	UniProt (Q6GQG6) Pfam (PF03066) UniProt (by SIFTS) (P05221)	XENOPUS LAEVIS (AFRICAN CLAWED FROG)	CORE NUCLEOPLASMIN WITH 8 MUTATIONS
3	K, L, M, N, O... (A, B, C, D, E...)	water	water		18.0	173	Chemie (HOH)

Sequence modifications

A, B, C, D, E, G, H, I, K: 1 - 120 (UniProt: Q6GQG6)

PDB	External Database	Details
Asp 3	Ser 3	engineered mutation
Asp 4	Thr 4	engineered mutation
Asp 6	Ser 6	engineered mutation
Asp 8	Thr 8	engineered mutation
Asp 9	Ser 9	engineered mutation
Asp 16	Ser 16	engineered mutation
Asp 67	Thr 67	engineered mutation
Asp 97	Thr 97	engineered mutation

J: 1 - 120 (UniProt: Q6GQG6)

PDB	External Database	Details
Asp 3	Ser 3	engineered mutation
Asp 4	Thr 4	engineered mutation
Asp 6	Ser 6	engineered mutation
Asp 8	Thr 8	engineered mutation
Asp 9	Ser 9	engineered mutation
Asp 16	Ser 16	engineered mutation
Asp 67	Thr 67	engineered mutation
Val 75	Ser 75	conflict
Asp 97	Thr 97	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	133853.7
All*	Total formula weight	133853.7

*Water molecules are not included.