2VF0
CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH 5NO2DUMP AND BW1843U89
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | THYMIDYLATE SYNTHASE | polymer | 264 | 30558.6 | 2 | UniProt (P0A884) Pfam (PF00303) | ESCHERICHIA COLI | TS, TSASE, |
| 2 | C, E (A, B) | 2'-DEOXY-5-NITROURIDINE 5'-MONOPHOSPHATE | non-polymer | 355.2 | 2 | Chemie (NDU) | |||
| 3 | D, F (A, B) | S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID | non-polymer | 500.5 | 2 | Chemie (F89) | |||
| 4 | G (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 264 (UniProt: P0A884)
| PDB | External Database | Details |
|---|---|---|
| Gln 48 | Lys 48 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61117.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1807.5 | |
| All* | Total formula weight | 62924.7 |
