2VBO

Molecular basis of human XPC gene recognition and cleavage by engineered homing endonuclease heterodimers

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA ENDONUCLEASE I-CREI	polymer	153	17529.2	1	UniProt (P05725) Pfam (PF00961)	CHLAMYDOMONAS REINHARDTII	23S RRNA INTRON PROTEIN, INI3-4-CA
2	B (B)	DNA ENDONUCLEASE I-CREI	polymer	153	17578.3	1	UniProt (P05725) Pfam (PF00961)	CHLAMYDOMONAS REINHARDTII	23S RRNA INTRON PROTEIN, INI3-4-CA
3	C (C)	5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3'	polymer	24	7410.8	1
4	D (E)	5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3'	polymer	24	7325.7	1
5	E, F, G, H (A, B)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	I, J, K, L (A, B, C, E)	water	water		18.0	349	Chemie (HOH)

Sequence modifications

A: 1 - 153 (UniProt: P05725)

PDB	External Database	Details
Ser 33	Tyr 33	conflict
Arg 38	Gln 38	conflict
Thr 42	Ala 42	conflict
Ser 70	Arg 70	conflict
Asn 75	Asp 75	conflict
Glu 110	Trp 110	conflict
Gln 111	Arg 111	conflict

B: 1 - 153 (UniProt: P05725)

PDB	External Database	Details
Glu 28	Lys 28	conflict
Arg 38	Gln 38	conflict
Lys 40	Ser 40	conflict
Thr 42	Ala 42	conflict
Lys 44	Gln 44	conflict
Ser 68	Arg 68	conflict
Ser 70	Arg 70	conflict
Asn 75	Asp 75	conflict
Glu 110	Trp 110	conflict
Gln 111	Arg 111	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	49844.0
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	50004.3

*Water molecules are not included.