2V5W
Crystal structure of HDAC8-substrate complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HISTONE DEACETYLASE 8 | polymer | 388 | 43158.9 | 2 | UniProt (Q9BY41) Pfam (PF00850) | HOMO SAPIENS (HUMAN) | HDAC8, HD8 |
| 2 | C (G) | GLYCYL-GLYCYL-GLYCINE | polymer | 3 | 189.2 | 1 | SYNTHETIC CONSTRUCT | ||
| 3 | D, E (I, L) | PEPTIDIC SUBSTRATE | polymer | 6 | 837.0 | 2 | UniProt (by SIFTS) (P04637) | SYNTHETIC CONSTRUCT | |
| 4 | F, G, I, J (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | H, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | L, M, N, O, P (A, B, G, I, L) | water | water | 18.0 | 746 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
A, B: 378 - 388 (PDB: 2V5W)
| PDB | External Database | Details |
|---|---|---|
| Phe 306 | Tyr 306 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 88181.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 287.2 | |
| All* | Total formula weight | 88468.2 |
