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2V2D

The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ATRIOSEPHOSPHATE ISOMERASE GLYCOSOMALpolymer24226075.81UniProt (P04789)
Pfam (PF00121)
In PDB
TRYPANOSOMA BRUCEI BRUCEITIM, TRIOSE- PHOSPHATE ISOMERASE
2APHOSPHATE IONnon-polymer95.01Chemie (PO4)
3waterwater18.0133Chemie (HOH)
Sequence modifications
A: 15 - 72 (UniProt: P04789)
PDBExternal DatabaseDetails
Ser 15Asn 15conflict
Pro 18Gln 18conflict
Asp 19Gln 19conflict
Gly 68Ile 68conflict
Asn 69Ala 69conflict
Ala 70Lys 70conflict
Asp 71Ser 71conflict
Ala 72Gly 72conflict
A: 80 - 250 (UniProt: P04789)
PDBExternal DatabaseDetails
Ala 81Pro 81conflict
Ser 82Ile 82conflict
Trp 100Ala 100conflict
Leu 178Ala 178engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight26075.8
Non-Polymers*Number of molecules1
Total formula weight95.0
All*Total formula weight26170.8
*Water molecules are not included.

217705

PDB entries from 2024-03-27

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