2V2D
The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL | polymer | 242 | 26075.8 | 1 | UniProt (P04789) Pfam (PF00121) In PDB | TRYPANOSOMA BRUCEI BRUCEI | TIM, TRIOSE- PHOSPHATE ISOMERASE |
2 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
3 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 15 - 72 (UniProt: P04789)
A: 80 - 250 (UniProt: P04789)
PDB | External Database | Details |
---|---|---|
Ser 15 | Asn 15 | conflict |
Pro 18 | Gln 18 | conflict |
Asp 19 | Gln 19 | conflict |
Gly 68 | Ile 68 | conflict |
Asn 69 | Ala 69 | conflict |
Ala 70 | Lys 70 | conflict |
Asp 71 | Ser 71 | conflict |
Ala 72 | Gly 72 | conflict |
PDB | External Database | Details |
---|---|---|
Ala 81 | Pro 81 | conflict |
Ser 82 | Ile 82 | conflict |
Trp 100 | Ala 100 | conflict |
Leu 178 | Ala 178 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 26075.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 95.0 | |
All* | Total formula weight | 26170.8 |