2V22
REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | CELL DIVISION PROTEIN KINASE 2 | polymer | 298 | 33976.5 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | P33 PROTEIN KINASE, CYCLIN-DEPENDENT KINASE 2 |
2 | B, D | CYCLIN-A2 | polymer | 259 | 29753.4 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | HOMO SAPIENS (HUMAN) | CYCLIN-A |
3 | B, D | N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE | non-polymer | 784.3 | 2 | Chemie (C35) | |||
4 | water | water | 18.0 | 323 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 127459.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1568.6 | |
All* | Total formula weight | 129028.4 |