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2V22

REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, CCELL DIVISION PROTEIN KINASE 2polymer29833976.52UniProt (P24941)
Pfam (PF00069)
In PDB
HOMO SAPIENS (HUMAN)P33 PROTEIN KINASE, CYCLIN-DEPENDENT KINASE 2
2B, DCYCLIN-A2polymer25929753.42UniProt (P20248)
Pfam (PF00134)
Pfam (PF02984)
In PDB
HOMO SAPIENS (HUMAN)CYCLIN-A
3B, DN~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDEnon-polymer784.32Chemie (C35)
4waterwater18.0323Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight127459.8
Non-Polymers*Number of molecules2
Total formula weight1568.6
All*Total formula weight129028.4
*Water molecules are not included.

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PDB entries from 2024-03-27

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