2UZU
PKA structures of indazole-pyridine series of AKT inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT | polymer | 336 | 39216.1 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | BOS TAURUS (BOVINE) | PKA C-ALPHA, PROTEIN KINASE A |
| 2 | I | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA | polymer | 20 | 2226.4 | 1 | UniProt (Q3SX13) In PDB | BOS TAURUS (BOVINE) | PKI-ALPHA |
| 3 | E | (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | non-polymer | 397.5 | 1 | Chemie (L20) |
Sequence modifications
E: 15 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Asp 286 | Asn 286 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41442.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 397.5 | |
| All* | Total formula weight | 41839.9 |
