2UW4
Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT | polymer | 351 | 40830.6 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | BOS TAURUS (BOVINE) | PKA C-ALPHA, PROTEIN KINASE A |
2 | I | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA | polymer | 20 | 2226.4 | 1 | UniProt (P61925) In PDB | HOMO SAPIENS | PKI-ALPHA, CAMP- DEPENDENT PROTEIN KINASE INHIBITOR, MUSCLE/BRAIN ISOFORM PKI |
3 | A | 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE | non-polymer | 201.3 | 1 | Chemie (L15) | |||
4 | water | water | 18.0 | 391 | Chemie (HOH) |
Sequence modifications
A: 0 - 0 (PDB: 2UW4)
A: 1 - 350 (UniProt: P00517)
A: 1 - 350 (UniProt: P00517)
PDB | External Database | Details |
---|---|---|
Thr 104 | Val 104 | engineered mutation |
Ala 123 | Val 123 | engineered mutation |
Met 173 | Leu 173 | engineered mutation |
Lys 181 | Gln 181 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43057.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 201.3 | |
All* | Total formula weight | 43258.3 |