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2UUE

REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors

Replaces:  2C5T
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
CELL DIVISION PROTEIN KINASE 2polymer29833976.52UniProt (P24941)
Pfam (PF00069)
HOMO SAPIENS (HUMAN)CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
2B, D
(B, D)
CYCLIN A2polymer25929753.42UniProt (P20248)
Pfam (PF00134)
Pfam (PF02984)
HOMO SAPIENS (HUMAN)CYCLIN A
3E, F
(E, F)
GVC-TETRAPEPTIDE INHIBITORpolymer5564.72synthetic construct
4G, H
(A, C)
4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINEnon-polymer368.52Chemie (MTZ)
5I, J
(E, F)
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDnon-polymer272.12Chemie (GVC)
6K, L, M, N, O...
(A, B, C, D, E...)
waterwater18.0244Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight128589.2
Non-Polymers*Number of molecules4
Total formula weight1281.1
All*Total formula weight129870.3
*Water molecules are not included.

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PDB entries from 2025-06-11

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