2ROC

Solution structure of Mcl-1 Complexed with Puma

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog	polymer	162	18260.7	1	UniProt (P97287) Pfam (PF00452)	Mus musculus (Mouse)	Bcl-2-related protein EAT/mcl1, Mcl-1
2	B (B)	Bcl-2-binding component 3	polymer	27	3324.7	1	UniProt (Q99ML1)	Mus musculus (Mouse)	p53 up-regulated modulator of apoptosis, Puma

Sequence modifications

A: 152 - 308 (UniProt: P97287)

PDB	External Database	Details
Gly 147	-	expression tag
Pro 148	-	expression tag
Leu 149	-	expression tag
Gly 150	-	expression tag
Ser 151	-	expression tag

B: 130 - 155 (UniProt: Q99ML1)

PDB	External Database	Details
Ile 144	Met 144	engineered mutation
Met 156	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21585.3
All*	Total formula weight	21585.3

*Water molecules are not included.