2RL5
Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vascular endothelial growth factor receptor 2 | polymer | 314 | 36284.6 | 1 | UniProt (P35968) Pfam (PF07714) In PDB | Homo sapiens (human) | VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen |
| 2 | A | N-(4-CHLOROPHENYL)-7-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]-2,3-DIHYDRO-1,4-BENZOXAZINE-4-CARBOXAMIDE | non-polymer | 491.9 | 1 | Chemie (2RL) | |||
| 3 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 815 - 939 (UniProt: P35968)
A: 990 - 1171 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Ala 817 | Cys 817 | engineered mutation |
| Thr 916 | Val 916 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Val 990 | Glu 990 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36284.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 491.9 | |
| All* | Total formula weight | 36776.5 |
