2RKF
HIV-1 PR resistant mutant + LPV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10783.7 | 2 | UniProt (A0F7J4) Pfam (PF00077) UniProt (by SIFTS) (Q90JJ9) | human immunodeficiency virus 1 (HIV-1) | HIV-1 PROTEASE |
| 2 | C, F (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (A) | N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | non-polymer | 628.8 | 1 | Chemie (AB1) | |||
| 4 | E, G (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: A0F7J4)
| PDB | External Database | Details |
|---|---|---|
| Val 13 | Ile 13 | engineered mutation |
| Ala 16 | Gly 16 | engineered mutation |
| Met 20 | Lys 20 | engineered mutation |
| Ser 37 | Asn 37 | engineered mutation |
| Val 46 | Ile 46 | engineered mutation |
| Met 54 | Leu 54 | engineered mutation |
| Leu 63 | Pro 63 | engineered mutation |
| Ile 93 | Leu 93 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21567.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1005.1 | |
| All* | Total formula weight | 22572.4 |
