2RII

Crystal Structure of Human Peroxiredoxin I in complex with Sulfiredoxin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxiredoxin-1	polymer	199	22133.2	2	UniProt (Q06830) Pfam (PF00578) Pfam (PF10417)	Homo sapiens (human)	Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, Proliferation-associated gene protein, PAG, Natural killer cell-enhancing factor A, NKEF-A
2	C, D (X, Y)	Sulfiredoxin-1	polymer	110	12034.7	2	UniProt (Q9BYN0)	Homo sapiens (human)
3	E, F (X, Y)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	G, H, I, J (A, B, X, Y)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B: 1 - 199 (UniProt: Q06830)

PDB	External Database	Details
Ser 71	Cys 71	engineered mutation
Glu 83	Cys 83	engineered mutation
Ser 173	Cys 173	engineered mutation

X, Y: 32 - 137 (UniProt: Q9BYN0)

PDB	External Database	Details
Gly 28	-	expression tag
His 29	-	expression tag
Pro 30	-	expression tag
Met 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	68335.7
Non-Polymers*	Number of molecules	2
	Total formula weight	189.9
All*	Total formula weight	68525.7

*Water molecules are not included.