2RG9
Crystal structure of viscum album mistletoe lectin I in native state at 1.95 A resolution, comparison of structure active site conformation in ricin and in viscumin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-galactoside-specific lectin 1 chain A isoform 1 | polymer | 249 | 27616.0 | 1 | UniProt (P81446) Pfam (PF00161) | Viscum album (European mistletoe) | Beta-galactoside-specific lectin I chain A isoform 1, MLA, ML-I A, rRNA N-glycosidase |
| 2 | B (B) | Beta-galactoside-specific lectin 1 chain B | polymer | 263 | 28753.2 | 1 | UniProt (P81446) Pfam (PF00652) | Viscum album (European mistletoe) | Beta-galactoside-specific lectin I chain B, MLB, ML-I B |
| 3 | C, P, Q, R (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, S, T (A, B) | AZIDE ION | non-polymer | 42.0 | 3 | Chemie (AZI) | |||
| 6 | F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | AA, H, I, J, K... (B, A) | GLYCEROL | non-polymer | 92.1 | 15 | Chemie (GOL) | |||
| 8 | BA, CA (A, B) | water | water | 18.0 | 317 | Chemie (HOH) |
Sequence modifications
A: 1 - 249 (UniProt: P81446)
B: 1 - 263 (UniProt: P81446)
| PDB | External Database | Details |
|---|---|---|
| Ser 5 | Arg 38 | conflict |
| Thr 8 | Val 41 | conflict |
| Val 9 | Thr 42 | conflict |
| Gln 10 | His 43 | conflict |
| Ser 19 | Arg 52 | conflict |
| Phe 27 | Tyr 60 | conflict |
| Asn 36 | Glu 69 | conflict |
| Glu 49 | Asp 82 | conflict |
| Ser 51 | Gln 84 | conflict |
| Gln 84 | Asp 117 | conflict |
| Lys 90 | Arg 123 | conflict |
| Gln 99 | His 132 | conflict |
| Asp 100 | Leu 133 | conflict |
| His 208 | Gln 241 | conflict |
| Leu 222 | Ile 255 | conflict |
| Val 227 | Phe 260 | conflict |
| Ile 233 | Val 266 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 11 | Thr 312 | conflict |
| Thr 21 | Cys 322 | conflict |
| Gln 30 | His 331 | conflict |
| Lys 54 | Arg 355 | conflict |
| Ile 90 | Leu 391 | conflict |
| Gln 92 | Glu 393 | conflict |
| Thr 166 | Val 467 | conflict |
| Gly 168 | Ser 469 | conflict |
| Glu 170 | Gln 471 | conflict |
| Ser 189 | Asp 490 | conflict |
| Asn 194 | Cys 495 | conflict |
| Asn 254 | Lys 555 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56369.2 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2559.3 | |
| All* | Total formula weight | 58928.4 |
