2RFS
X-ray structure of SU11274 bound to c-Met
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 310 | 35346.9 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
| 2 | B (A) | N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide | non-polymer | 456.0 | 1 | Chemie (AM8) | |||
| 3 | C (A) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 1048 - 1351 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 1047 | - | initiating methionine |
| Leu 1272 | Val 1272 | conflict |
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
| His 1356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35346.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 456.0 | |
| All* | Total formula weight | 35802.9 |
