2RFN

x-ray structure of c-Met with inhibitor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Hepatocyte growth factor receptor	polymer	310	35346.9	2	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (human)	HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met
2	A, B	2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3H)-one	non-polymer		610.7	2	Chemie (AM7)
3		water	water		18.0	167	Chemie (HOH)

Sequence modifications

A, B: 1048 - 1351 (UniProt: P08581)

PDB	External Database	Details
Met 1047	-	initiating methionine
Leu 1272	Val 1272	conflict
His 1352	-	expression tag
His 1353	-	expression tag
His 1354	-	expression tag
His 1355	-	expression tag
His 1356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70693.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1221.3
All*	Total formula weight	71915.2

*Water molecules are not included.