2RF9

Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Epidermal growth factor receptor	polymer	330	37563.5	2	UniProt (P00533) Pfam (PF07714)	Homo sapiens (human)	Receptor tyrosine-protein kinase ErbB-1
2	C, D (C, D)	ERBB receptor feedback inhibitor 1	polymer	65	6866.7	2	UniProt (Q9UJM3) Pfam (PF11555)	Homo sapiens (human)	Mitogen-inducible gene 6 protein, Mig-6

Sequence modifications

A, B: 672 - 998 (UniProt: P00533)

PDB	External Database	Details
Gly 669	-	expression tag
Ala 670	-	expression tag
Met 671	-	expression tag

C, D: 315 - 374 (UniProt: Q9UJM3)

PDB	External Database	Details
Gly 310	-	expression tag
Pro 311	-	expression tag
Leu 312	-	expression tag
Gly 313	-	expression tag
Ser 314	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88860.3
All*	Total formula weight	88860.3

*Water molecules are not included.