2RF0

Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Mitogen-activated protein kinase kinase kinase 10	polymer	89	9734.6	4	UniProt (Q02779) Pfam (PF14604) In PDB	Homo sapiens (human)	Mixed lineage kinase 2, Protein kinase MST
2	A, D	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3		water	water		18.0	84	Chemie (HOH)

Sequence modifications

A, B, C, D: 13 - 78 (UniProt: Q02779)

PDB	External Database	Details
Met -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Val 0	-	expression tag
Asp 1	-	expression tag
Leu 2	-	expression tag
Gly 3	-	expression tag
Thr 4	-	expression tag
Glu 5	-	expression tag
Asn 6	-	expression tag
Leu 7	-	expression tag
Tyr 8	-	expression tag
Phe 9	-	expression tag
Gln 10	-	expression tag
Ser 11	-	expression tag
Met 12	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	38938.4
Non-Polymers*	Number of molecules	2
	Total formula weight	124.1
All*	Total formula weight	39062.5

*Water molecules are not included.