2RED
Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide | polymer | 121 | 14375.6 | 1 | UniProt (O00443) Pfam (PF00787) | Homo sapiens (human) | Phosphoinositide 3-Kinase-C2-alpha, PtdIns-3-kinase C2 alpha, PI3K-C2alpha |
| 2 | B, C, D, E, F... (A) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 3 | H (A) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 1421 - 1532 (UniProt: O00443)
| PDB | External Database | Details |
|---|---|---|
| Met 1420 | - | expression tag |
| Gly 1533 | - | expression tag |
| Ser 1534 | - | expression tag |
| His 1535 | - | expression tag |
| His 1536 | - | expression tag |
| His 1537 | - | expression tag |
| His 1538 | - | expression tag |
| His 1539 | - | expression tag |
| His 1540 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14375.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 552.6 | |
| All* | Total formula weight | 14928.1 |
