2R8K

Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (Q, P)	5'-D(*DGP*DTP*DGP*DGP*DTP*DGP*DAP*DGP*DC)-3'	polymer	9	2811.8	2
2	B, D (U, T)	5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DCP*DCP*DAP*DC)-3'	polymer	10	2990.0	2
3	E, F (A, B)	DNA polymerase eta	polymer	554	62617.8	2	UniProt (Q04049) Pfam (PF00817) Pfam (PF11799)	Saccharomyces cerevisiae (baker's yeast)	Radiation sensitive protein 30
4	G, H (U, T)	Cisplatin	non-polymer		300.0	2	Chemie (CPT)
5	I, J, L, M (A, B)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA) PubChem (271)
6	K, N (A, B)	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	2	Chemie (DTP) PubChem (622) PubChem (15993) PubChem (448808) PubChem (44119995) PubChem (46936612) PubChem (89346292) PubChem (57233913) PubChem (91632917) PubChem (92341128) PubChem (92449119) PubChem (92449120) PubChem (129069956) PubChem (171699368)

Sequence modifications

A, B: 1 - 531 (UniProt: Q04049)

PDB	External Database	Details
Met -22	-	expression tag
Ala -21	-	expression tag
Ser -20	-	expression tag
Trp -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Gln -15	-	expression tag
Phe -14	-	expression tag
Glu -13	-	expression tag
Lys -12	-	expression tag
Gly -11	-	expression tag
Ala -10	-	expression tag
Ser -9	-	expression tag
Thr -8	-	expression tag
Ser -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Lys -3	-	expression tag
Ala -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	136839.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1742.8
All*	Total formula weight	138582.0

*Water molecules are not included.