2R8K

Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	Q, P	5'-D(*DGP*DTP*DGP*DGP*DTP*DGP*DAP*DGP*DC)-3'	polymer	9	2811.8	2
2	U, T	5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DCP*DCP*DAP*DC)-3'	polymer	10	2990.0	2
3	A, B	DNA polymerase eta	polymer	554	62617.8	2	UniProt (Q04049) Pfam (PF00817) In PDB	Saccharomyces cerevisiae (baker's yeast)	Radiation sensitive protein 30
4	U, T	Cisplatin	non-polymer		300.0	2	Chemie (CPT)
5	A, B	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	A, B	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	2	Chemie (DTP)

Sequence modifications

A, B: 1 - 531 (UniProt: Q04049)

PDB	External Database	Details
Met -22	-	expression tag
Ala -21	-	expression tag
Ser -20	-	expression tag
Trp -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Gln -15	-	expression tag
Phe -14	-	expression tag
Glu -13	-	expression tag
Lys -12	-	expression tag
Gly -11	-	expression tag
Ala -10	-	expression tag
Ser -9	-	expression tag
Thr -8	-	expression tag
Ser -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Lys -3	-	expression tag
Ala -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	136839.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1742.8
All*	Total formula weight	138582.0

*Water molecules are not included.