2R8K
Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (Q, P) | 5'-D(*DGP*DTP*DGP*DGP*DTP*DGP*DAP*DGP*DC)-3' | polymer | 9 | 2811.8 | 2 | |||
| 2 | B, D (U, T) | 5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DCP*DCP*DAP*DC)-3' | polymer | 10 | 2990.0 | 2 | |||
| 3 | E, F (A, B) | DNA polymerase eta | polymer | 554 | 62617.8 | 2 | UniProt (Q04049) Pfam (PF00817) Pfam (PF11799) | Saccharomyces cerevisiae (baker's yeast) | Radiation sensitive protein 30 |
| 4 | G, H (U, T) | Cisplatin | non-polymer | 300.0 | 2 | Chemie (CPT) | |||
| 5 | I, J, L, M (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | K, N (A, B) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 2 | Chemie (DTP) |
Sequence modifications
A, B: 1 - 531 (UniProt: Q04049)
| PDB | External Database | Details |
|---|---|---|
| Met -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Ser -20 | - | expression tag |
| Trp -19 | - | expression tag |
| Ser -18 | - | expression tag |
| His -17 | - | expression tag |
| Pro -16 | - | expression tag |
| Gln -15 | - | expression tag |
| Phe -14 | - | expression tag |
| Glu -13 | - | expression tag |
| Lys -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 136839.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1742.8 | |
| All* | Total formula weight | 138582.0 |
