2R7E
Crystal Structure Analysis of Coagulation Factor VIII
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor VIII | polymer | 742 | 84950.0 | 1 | UniProt (P00451) Pfam (PF07732) | Homo sapiens (human) | |
| 2 | B (B) | Coagulation factor VIII | polymer | 770 | 88917.6 | 1 | UniProt (P00451) Pfam (PF07731) Pfam (PF00754) | Homo sapiens (human) | |
| 3 | C (C) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-2)-beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G71177VF) | |||
| 6 | F, G, H (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 7 | I, J (A, B) | COPPER (II) ION | non-polymer | 63.5 | 2 | Chemie (CU) |
Sequence modifications
B: 1563 - 2332 (UniProt: P00451)
| PDB | External Database | Details |
|---|---|---|
| Ser 1838 | Phe 1857 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 173867.6 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2408.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 247.3 | |
| All* | Total formula weight | 176523.1 |
