2R6Y
Estrogen receptor alpha ligand-binding domain in complex with a SERM
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Estrogen receptor | polymer | 248 | 28297.2 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
2 | A, B | [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl][4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone | non-polymer | 459.6 | 2 | Chemie (LLC) | |||
3 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A, B: 304 - 551 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Ser 381 | Cys 381 | engineered mutation |
Ser 417 | Cys 417 | engineered mutation |
Ser 530 | Cys 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 56594.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 919.1 | |
All* | Total formula weight | 57513.5 |