2QWC
THE X-RAY STRUCTURE OF A COMPLEX OF NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NEURAMINIDASE | polymer | 388 | 43695.8 | 1 | UniProt (P03472) | Influenza A virus | SIALIDASE |
| 2 | B (B) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G46836GH) | |||
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, F (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 6 | G (A) | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID | non-polymer | 291.3 | 1 | Chemie (DAN) PubChem (1553) PubChem (44299597) PubChem (44305374) PubChem (44314809) PubChem (44353094) PubChem (44387099) PubChem (44629965) PubChem (65309) PubChem (49819354) PubChem (196123) PubChem (57673682) PubChem (440392) PubChem (50986297) PubChem (71299570) PubChem (71312796) PubChem (492456) PubChem (68019401) PubChem (5329058) PubChem (93616863) PubChem (101008065) PubChem (102094437) PubChem (13728878) PubChem (15956564) PubChem (132002898) PubChem (133688885) | |||
| 7 | H (A) | water | water | 18.0 | 390 | Chemie (HOH) |
Sequence modifications
A: 82 - 468 (UniProt: P03472)
| PDB | External Database | Details |
|---|---|---|
| Lys 292 | Arg 294 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43695.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1659.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 592.6 | |
| All* | Total formula weight | 45947.9 |
