2QUR
Crystal Structure of F327A/K285P Mutant of cAMP-dependent Protein Kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 350 | 40549.2 | 1 | UniProt (P05132) Pfam (PF00069) | Mus musculus | PKA C-alpha |
| 2 | B (B) | 20-mer fragment from cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P63248) | ||
| 3 | C (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P05132)
| PDB | External Database | Details |
|---|---|---|
| Tpo 197 | Thr 198 | modified residue |
| Pro 285 | Lys 286 | engineered mutation |
| Ala 327 | Phe 328 | engineered mutation |
| Sep 338 | Ser 339 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42775.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 427.2 | |
| All* | Total formula weight | 43202.8 |
