2QU5
Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Vascular endothelial growth factor receptor 2 | polymer | 314 | 36284.6 | 1 | UniProt (P35968) Pfam (PF07714) In PDB | Homo sapiens (human) | VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen |
2 | A | 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide | non-polymer | 461.8 | 1 | Chemie (276) | |||
3 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 815 - 939 (UniProt: P35968)
A: 990 - 1171 (UniProt: P35968)
PDB | External Database | Details |
---|---|---|
Ala 817 | Cys 817 | engineered mutation |
Thr 916 | Val 916 | engineered mutation |
Arg 1172 | - | expression tag |
His 1173 | - | expression tag |
His 1174 | - | expression tag |
His 1175 | - | expression tag |
His 1176 | - | expression tag |
His 1177 | - | expression tag |
His 1178 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Val 990 | Glu 990 | engineered mutation |
Ptr 1054 | Tyr 1054 | modified residue |
Ptr 1059 | Tyr 1059 | modified residue |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36284.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 461.8 | |
All* | Total formula weight | 36746.4 |