2QTW

The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proprotein convertase subtilisin/kexin type 9 Propeptide	polymer	124	14019.7	1	UniProt (Q8NBP7) Pfam (PF05922) In PDB	Homo sapiens (human)	Proprotein convertase PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1
2	B	Proprotein convertase subtilisin/kexin type 9	polymer	546	58272.6	1	UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) In PDB	Homo sapiens (human)	Proprotein convertase PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1
3	B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
4	B	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5		water	water		18.0	320	Chemie (HOH)

Sequence modifications

B: 153 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
His 693	-	expression tag
His 694	-	expression tag
His 695	-	expression tag
His 696	-	expression tag
His 697	-	expression tag
His 698	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72292.4
Non-Polymers*	Number of molecules	2
	Total formula weight	261.3
All*	Total formula weight	72553.6

*Water molecules are not included.