2QDM

Crystal structure of the HePTP catalytic domain C270S/D236A/Q314A mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein phosphatase non-receptor type 7	polymer	309	35218.9	1	UniProt (P35236) Pfam (PF00102)	Homo sapiens (human)	Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP
2	B, C (A)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	D (A)	water	water		18.0	186	Chemie (HOH)

Sequence modifications

A: 44 - 339 (UniProt: P35236)

PDB	External Database	Details
Met -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
Asp -9	-	expression tag
Lys -8	-	expression tag
Ile -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag
Ala 236	Asp 257	engineered mutation
Ser 270	Cys 291	engineered mutation
Ala 314	Gln 335	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35218.9
Non-Polymers*	Number of molecules	2
	Total formula weight	189.9
All*	Total formula weight	35408.8

*Water molecules are not included.