2QD1
2.2 Angstrom Structure of the human ferrochelatase variant E343K with substrate bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Ferrochelatase | polymer | 359 | 41178.5 | 4 | UniProt (P22830) Pfam (PF00762) In PDB | Homo sapiens (human) | Protoheme ferro-lyase, Heme synthetase |
| 2 | A, B, C, D | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) | |||
| 3 | A, B, C, D | PROTOPORPHYRIN IX | non-polymer | 562.7 | 6 | Chemie (PP9) | |||
| 4 | D | CHOLIC ACID | non-polymer | 408.6 | 2 | Chemie (CHD) | |||
| 5 | D | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 6 | water | water | 18.0 | 686 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 65 - 423 (UniProt: P22830)
| PDB | External Database | Details |
|---|---|---|
| Lys 343 | Glu 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164713.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 4965.5 | |
| All* | Total formula weight | 169679.3 |
