2QCL
Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to OMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Uridine 5'-monophosphate synthase (UMP synthase) | polymer | 260 | 28298.8 | 2 | UniProt (P11172) Pfam (PF00215) | Homo sapiens (human) | |
| 2 | C, E (A, B) | OROTIDINE-5'-MONOPHOSPHATE | non-polymer | 368.2 | 2 | Chemie (OMP) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 406 | Chemie (HOH) |
Sequence modifications
A, B: 224 - 480 (UniProt: P11172)
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | expression tag |
| Ala 222 | - | expression tag |
| Met 223 | - | expression tag |
| Asn 312 | Asp 312 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56597.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 828.5 | |
| All* | Total formula weight | 57426.0 |
