2QAK
HIV-1 PR mutant in complex with nelfinavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10762.7 | 2 | UniProt (P03367) Pfam (PF00077) | human immunodeficiency virus 1 (HIV-1) | HIV-1 PROTEASE |
| 2 | C (A) | 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE | non-polymer | 567.8 | 1 | Chemie (1UN) PubChem (64143) PubChem (480161) PubChem (54217552) PubChem (54217553) PubChem (54592289) PubChem (58649028) PubChem (59908248) PubChem (71055744) PubChem (67020344) PubChem (73265381) PubChem (73707414) PubChem (4451) PubChem (6540553) PubChem (6540606) PubChem (92143146) PubChem (92209966) PubChem (92209967) PubChem (12047302) PubChem (92169363) PubChem (5279250) PubChem (121366724) PubChem (129010286) PubChem (10578931) PubChem (10721715) PubChem (118986644) PubChem (122130286) PubChem (12031087) PubChem (124870678) PubChem (124870679) PubChem (137704597) PubChem (138107019) PubChem (129606837) PubChem (15380025) PubChem (15380026) PubChem (141869355) PubChem (145813677) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Asn 30 | Asp 98 | engineered mutation |
| Ala 55 | Lys 123 | engineered mutation |
| Met 90 | Leu 158 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21525.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 567.8 | |
| All* | Total formula weight | 22093.2 |
