2QAB
Crystal Structure of Estrogen Receptor Alpha Ligand Binding Domain Mutant 537S Complexed with an Ethyl Indazole Compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 258 | 29386.6 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | C, D (C, D) | nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q8BN74) UniProt (by SIFTS) (Q61026) | Mus musculus | |
| 3 | E, F (A, B) | 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL | non-polymer | 254.3 | 2 | Chemie (EI1) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61932.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 508.6 | |
| All* | Total formula weight | 62441.5 |
