2QA8
Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Mutant 537S Complexed with Genistein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 258 | 29462.7 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | B (B) | Estrogen receptor | polymer | 258 | 29462.7 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 3 | C, D (C, D) | nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q8BN74) UniProt (by SIFTS) (Q61026) | Mus musculus | |
| 4 | E, F (A, B) | GENISTEIN | non-polymer | 270.2 | 2 | Chemie (GEN) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 70 | Chemie (HOH) |
Sequence modifications
A: 298 - 554 (UniProt: P03372)
B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | cloning artifact |
| Cme 530 | Cys 530 | modified residue |
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | cloning artifact |
| Cme 381 | Cys 381 | modified residue |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62085.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 540.5 | |
| All* | Total formula weight | 62625.7 |
