2QA8

Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Mutant 537S Complexed with Genistein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Estrogen receptor	polymer	258	29462.7	1	UniProt (P03372) Pfam (PF00104) In PDB	Homo sapiens (human)	ER, Estradiol receptor, ER-alpha
2	B	Estrogen receptor	polymer	258	29462.7	1	UniProt (P03372) Pfam (PF00104) In PDB	Homo sapiens (human)	ER, Estradiol receptor, ER-alpha
3	C, D	nuclear receptor coactivator 2	polymer	13	1579.9	2	UniProt (Q8BN74) UniProt (by SIFTS) (Q61026) In PDB	Mus musculus
4	A, B	GENISTEIN	non-polymer		270.2	2	Chemie (GEN)
5		water	water		18.0	70	Chemie (HOH)

Sequence modifications

A: 298 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 297	-	cloning artifact
Cme 530	Cys 530	modified residue
Ser 537	Tyr 537	engineered mutation

B: 298 - 554 (UniProt: P03372)

PDB	External Database	Details
Ser 297	-	cloning artifact
Cme 381	Cys 381	modified residue
Ser 537	Tyr 537	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	62085.2
Non-Polymers*	Number of molecules	2
	Total formula weight	540.5
All*	Total formula weight	62625.7

*Water molecules are not included.