2Q7L
The Androgen Receptor Prostate Cancer Mutant H874Y Ligand Binding Domain Bound with Testosterone and a TIF2 box3 Coactivator Peptide 740-753
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Androgen receptor | polymer | 257 | 30032.1 | 1 | UniProt (P10275) Pfam (PF00104) | Homo sapiens (human) | Dihydrotestosterone receptor |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 14 | 1708.9 | 1 | UniProt (Q15596) | Homo sapiens (human) | NCoA-2, Transcriptional intermediary factor 2 |
| 3 | C (A) | TESTOSTERONE | non-polymer | 288.4 | 1 | Chemie (TES) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 663 - 919 (UniProt: P10275)
| PDB | External Database | Details |
|---|---|---|
| Tyr 874 | His 874 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31741.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 380.5 | |
| All* | Total formula weight | 32121.6 |
