2Q0A
Structure and rearrangements in the carboxy-terminal region of SpIH channels
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | polymer | 200 | 23427.7 | 2 | UniProt (O88703) Pfam (PF00027) | Mus musculus (house mouse) | Brain cyclic nucleotide-gated channel 2, BCNG-2, Hyperpolarization-activated cation channel 1, HAC-1 |
| 2 | C, D (A, B) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 2 | Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, B: 443 - 640 (UniProt: O88703)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | cloning artifact |
| Ser 442 | - | cloning artifact |
| Asp 636 | Ile 636 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46855.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 690.4 | |
| All* | Total formula weight | 47545.9 |
