2PZP

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 2	polymer	324	37110.5	2	UniProt (P21802) Pfam (PF07714)	Homo sapiens (human)	FGFR-2, Keratinocyte growth factor receptor 2, CD332 antigen
2	C, D, H, I (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	E, F, J, K (A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	G, L (A, B)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	2	Chemie (ACP)
5	M, N (A, B)	water	water		18.0	147	Chemie (HOH)

Sequence modifications

A, B: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	expression tag
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Ala 491	Cys 491	engineered mutation
Glu 526	Lys 526	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74221.0
Non-Polymers*	Number of molecules	10
	Total formula weight	1491.9
All*	Total formula weight	75712.9

*Water molecules are not included.