2PZF

Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer with delta F508

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Cystic fibrosis transmembrane conductance regulator	polymer	228	25378.2	2	UniProt (P13569) Pfam (PF00005) In PDB	Homo sapiens (Human)	CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
4		water	water		18.0	130	Chemie (HOH)

Sequence modifications

A, B: 387 - 404 (UniProt: P13569)

PDB	External Database	Details
Ser 386	-	expression tag

A, B: 437 - 646 (UniProt: P13569)

PDB	External Database	Details
Met 470	Val 470	variant
-	Phe 508	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50756.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1063.0
All*	Total formula weight	51819.4

*Water molecules are not included.