2PYN
HIV-1 PR mutant in complex with nelfinavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10744.7 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (A) | 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE | non-polymer | 567.8 | 1 | Chemie (1UN) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Asn 30 | Asp 98 | engineered mutation |
| Ala 41 | Arg 109 | engineered mutation |
| Val 71 | Ala 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21489.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 567.8 | |
| All* | Total formula weight | 22057.2 |
