2PYE
Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry TCR Clone C5C1 Complexed with MHC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11853.3 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (C) | Cancer/testis antigen 1B | polymer | 9 | 1094.3 | 1 | UniProt (P78358) | L antigen family member 2, LAGE-2 protein, Autoimmunogenic cancer/testis antigen NY-ESO-1 | |
| 4 | D (D) | T-Cell Receptor, Alpha Chain | polymer | 195 | 21324.7 | 1 | UniProt (A2NVQ1) Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 5 | E (E) | T-Cell Receptor, Beta Chain | polymer | 242 | 27151.2 | 1 | UniProt (Q6NS87) | Homo sapiens (human) | |
| 6 | F, G, N, R, S... (A, B, D, E) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 7 | H, I, Y (A, E) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 8 | J (A) | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL | non-polymer | 310.4 | 1 | Chemie (7PE) | |||
| 9 | AA, BA, CA, K, L... (E, A, B, D) | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
| 10 | DA, EA, FA, GA, HA (A, B, C, D, E) | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | insertion |
| Cys 91 | Lys 111 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93374.8 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2638.5 | |
| All* | Total formula weight | 96013.4 |
