2PWL
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fibroblast growth factor receptor 2 | polymer | 324 | 37134.6 | 2 | UniProt (P21802) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-2, Keratinocyte growth factor receptor 2, CD332 antigen |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A, B | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 2 | Chemie (ACP) | |||
4 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 768 (UniProt: P21802)
PDB | External Database | Details |
---|---|---|
Met 445 | - | expression tag |
Gly 446 | - | expression tag |
Ser 447 | - | expression tag |
Ser 448 | - | expression tag |
His 449 | - | expression tag |
His 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
Ser 455 | - | expression tag |
Gln 456 | - | expression tag |
Asp 457 | - | expression tag |
Ala 491 | Cys 491 | engineered mutation |
His 549 | Asn 549 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 74269.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1394.7 | |
All* | Total formula weight | 75663.9 |