2PVV

Structure of human glutamate carboxypeptidase II (GCPII) in complex with L-serine-O-sulfate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamate carboxypeptidase 2	polymer	709	79859.0	1	UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253)	Homo sapiens (human)	Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Pteroylpoly-gamma-glutamate carboxypeptidase, Folylpoly-gamma- glutamate carboxypeptidase, FGCP, Folate hydrolase 1, Prostate- specific membrane antigen, PSMA, PSM
2	B, C, D (B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
3	E (E)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G48068RF)
4	F, G, H (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
5	I, J (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	K (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
7	L (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8	M (A)	O-SULFO-L-SERINE	non-polymer		185.2	1	Chemie (OSE)
9	N (A)	water	water		18.0	510	Chemie (HOH)

Sequence modifications

A: 44 - 750 (UniProt: Q04609)

PDB	External Database	Details
Arg 42	-	cloning artifact
Ser 43	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	79859.0
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1055.1
All*	Total formula weight	82936.0

*Water molecules are not included.