2PUU
Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 348 | 39800.6 | 1 | UniProt (P47811) Pfam (PF00069) | Mus musculus (mouse) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, CRK1 |
| 2 | B (A) | 5-TERT-BUTYL-2-(4-METHYLPHENYL)-3-{[({4-[6-(MORPHOLIN-4-YLMETHYL)PYRIDIN-3-YL]-1-NAPHTHYL}AMINO)CARBONYL]AMINO}-1H-PYRAZOL-2-IUM | non-polymer | 575.7 | 1 | Chemie (G2G) | |||
| 3 | C (A) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 5 - 352 (UniProt: P47811)
| PDB | External Database | Details |
|---|---|---|
| Ala 14 | Asn 14 | engineered mutation |
| Ala 120 | Gln 120 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39800.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 575.7 | |
| All* | Total formula weight | 40376.3 |
