2PO6

Crystal structure of CD1d-lipid-antigen complexed with Beta-2-Microglobulin, NKT15 Alpha-Chain and NKT15 Beta-Chain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	T-cell surface glycoprotein CD1d	polymer	278	31758.8	2	UniProt (P15813) Pfam (PF16497) Pfam (PF07654)	Homo sapiens (human)	CD1d antigen, R3G1
2	B, F (B, F)	Beta-2-microglobulin	polymer	99	11748.2	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)
3	C, G (C, G)	NKT15 alpha-chain	polymer	204	22664.0	2	UniProt (Q6PIZ8) Pfam (PF09291) UniProt (by SIFTS) (P01848)	Homo sapiens (human)
4	D, H (D, H)	NKT15 beta-chain	polymer	244	27772.9	2	UniProt (Q6GMR4)	Homo sapiens (human)
5	I (I)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		383.3	1	In PDB GlyTouCan (G90333CG)
6	J (J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	K, L, N (A, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
8	M, O (C, E)	N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE	non-polymer		858.3	2	Chemie (AGH)

Sequence modifications

A, E: 6 - 277 (UniProt: P15813)

PDB	External Database	Details
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	187887.6
Branched	Number of molecules	2
	Total formula weight	807.8
Non-Polymers*	Number of molecules	5
	Total formula weight	2380.3
All*	Total formula weight	191075.6

*Water molecules are not included.