2PE2
CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 3-{5-[2-Oxo-5-ureido-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrol-3-yl}-N-(2-piperidin-1-yl-ethyl)-benzamide COMPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 3-phosphoinositide-dependent protein kinase 1 | polymer | 286 | 33130.1 | 1 | UniProt (O15530) Pfam (PF00069) | Homo sapiens (human) | hPDK1 |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | 3-[5-({5-[(AMINOCARBONYL)AMINO]-2-OXO-2H-INDOL-3-YL}METHYL)-1H-PYRROL-3-YL]-N-(2-PIPERIDIN-1-YLETHYL)BENZAMIDE | non-polymer | 498.6 | 1 | Chemie (464) | |||
| 4 | F, G, H, I, J... (A) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | N (A) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 74 - 359 (UniProt: O15530)
| PDB | External Database | Details |
|---|---|---|
| Sep 241 | Ser 241 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33130.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1523.5 | |
| All* | Total formula weight | 34653.6 |
