2PDY
Human aldose reductase double mutant S302R-C303D complexed with fidarestat.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Aldose reductase | polymer | 316 | 35980.4 | 1 | UniProt (P15121) Pfam (PF00248) In PDB | Homo sapiens (human) | AR, Aldehyde reductase |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE | non-polymer | 279.2 | 1 | Chemie (FID) | |||
4 | water | water | 18.0 | 315 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
PDB | External Database | Details |
---|---|---|
Ile 4 | Leu 5 | conflict |
Arg 302 | Ser 303 | engineered mutation |
Asp 303 | Cys 304 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35980.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1022.6 | |
All* | Total formula weight | 37003.0 |