2PDJ
Human aldose reductase mutant L300A complexed with IDD393.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aldose reductase | polymer | 316 | 35856.3 | 1 | UniProt (P15121) Pfam (PF00248) In PDB | Homo sapiens (human) | AR, Aldehyde reductase |
| 2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | A | (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID | non-polymer | 364.7 | 1 | Chemie (393) | |||
| 4 | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Leu 5 | conflict |
| Ala 300 | Leu 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35856.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1108.1 | |
| All* | Total formula weight | 36964.4 |
